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Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides
Andreas Prestel1, Heiko M Möller2
1Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, 78464 Konstanz, Germany.
Chemical Communications (Cambridge, England)
|November 13, 2015
Abstract:
The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.
