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Updated: Mar 30, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
The enteric microbiome in hepatobiliary health and disease
James H Tabibian1, Cyril Varghese2, Nicholas F LaRusso3
1Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.
Abstract:
Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high-throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.
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