Biological variations of thirteen plasma biochemical indicators

Area of Science:

• Clinical Biochemistry
• Human Physiology

Background:

• Limited data exists on the biological variation of plasma biochemical indicators.
• Understanding these variations is crucial for accurate interpretation of laboratory results.

Purpose of the Study:

• To evaluate the biological variations of 13 key plasma biochemical indicators.
• To establish reference ranges and analytical goals based on biological variability.

Main Methods:

• Collected plasma samples from 40 healthy individuals over 5 days.
• Calculated intra-individual coefficient of variation (CVI), inter-individual coefficient of variation (CVG), index of individuality (II), and reference change value (RCV).

Main Results:

• Albumin (Alb) demonstrated the lowest CVI and CVG, while high-sensitivity C-reactive protein (hsCRP) showed the highest.
• Index of individuality (II) values were consistently below 1.0 for all indicators.
• Significant gender differences were observed in the CVI and CVG for several indicators, including Albumin, urea, creatinine, creatine kinase, and CKMBmass.

Conclusions:

• The study contributes valuable data to the understanding of plasma biochemical indicator biological variation.
• Findings underscore the need to consider biological variability, especially gender-specific differences, when interpreting test results.