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Published on: August 8, 2025
[Primary liver tumours in childhood]
D G Schreiber-Dietrich1, I Leuschner2, A Tannapfel3
1Pädiatrie, Caritas-Krankenhaus, Bad Mergentheim, Germany.
Insights
This article reviews pediatric liver tumors using histopathology and contrast-enhanced ultrasound (CEUS) features. It supports the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) registry for ultrasound contrast agents in children.
Area of Science:
- Pediatric Radiology
- Hepatology
- Medical Imaging
Background:
- Focal liver lesions exhibit varying prevalence in pediatric versus adult populations.
- Accurate diagnosis of pediatric liver tumors is crucial for appropriate management.
- Contrast-enhanced ultrasound (CEUS) is a valuable tool in evaluating liver lesions.
Purpose of the Study:
- To discuss pediatric liver tumors based on histopathology and contrast-enhanced ultrasound (CEUS) features.
- To support the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Pediatric Registry.
- To gather data on the safety and applications of ultrasound contrast agents in pediatric patients.
Main Methods:
- Review of histopathological criteria for pediatric liver tumors.
- Analysis of contrast-enhanced ultrasound (CEUS) features of pediatric liver lesions.
- Data collection through the EFSUMB Pediatric Registry.
Main Results:
- Specific histopathological findings associated with common pediatric liver tumors.
- Characteristic CEUS patterns differentiating various pediatric liver lesions.
- Initial data on the safety and efficacy of ultrasound contrast agents in children.
Conclusions:
- Histopathology and CEUS are essential for diagnosing pediatric liver tumors.
- The EFSUMB Pediatric Registry is vital for advancing knowledge on ultrasound contrast agents in children.
- Further data collection will refine the understanding of CEUS in pediatric liver lesion evaluation.
Abstract:
The reported prevalence of focal liver lesions in adult patients and children is different. The article discusses pediatric liver tumors under the criteria of histopathology and contrast enhanced ultrasound (CEUS) features. Aim of this article is also to support the already established Pediatric Registry of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) to collect data on safety and applications of ultrasound contrast agents in children (www.efsumb.org).
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