Related Experiment Video
Updated: Mar 30, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
Published on: October 8, 2021
Controllable Drug Release System in Living Cells Triggered by Enzyme-Substrate Recognition
Pengchang Liu1, Xiaoliang Wang1, Kalervo Hiltunen1,2
1State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, and International Joint Research Laboratory of Nano-Micro Architecture Chemistry, Jilin University , 2699 Qianjin Street, Chaoyang, Changchun, Jilin 130012, People's Republic of China.
Abstract:
Vehicles can deliver the drug molecules into cells, yet immunoreaction of the commonly used capping agents and release triggers limit their biomedical use. This shortcoming might be circumvented through replacing these chemicals with certain biomolecules. Here, we show a new and facile way to encapsulate the drug delivery vehicles and release the cargos in a highly controllable manner via modulating supramolecular interactions between enzyme, substrate, and vehicle. The cargo release from the vehicles within cells can be achieved upon substrate treatment. Yeast cells were used, allowing for a fast and cost-effective way for imaging and morphological analysis. We believe this new platform can be readily extended to various carrier systems for different purposes based on shifting the recognition pattern of enzyme-substrate pairs.
Related Concept Videos
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Rate-Programmed I
Modified-Release Drug Delivery Systems: Site-Targeted
Modified-Release Drug Delivery Systems: Drug Release Characteristics

