Chronic rhinosinusitis; histopathologic study of osteitis in surgery cases

Area of Science:

• Otolaryngology
• Pathology

Background:

• Chronic rhinosinusitis (CRS) is a prevalent condition impacting quality of life.
• Osteitis, a bone inflammation, is a potential complication in CRS management.

Purpose of the Study:

• To investigate the association between osteitis and primary versus revision endoscopic sinus surgery (ESS) in CRS patients.
• To explore the relationship between osteitis and mucosal inflammation in CRS.

Main Methods:

• Patients were categorized into primary (n=74) and revision (n=37) ESS groups.
• Histopathological examination of ethmoid bony septa and overlying mucosa was performed.

Main Results:

• Osteitis incidence was 56.8% in primary ESS and 70.3% in revision ESS groups (p=0.229).
• Osteitis showed a significant association with tissue eosinophilia (p=0.01) and inflammatory cell predominance (p=0.01).

Conclusions:

• Bone remodeling in CRS may not be primarily driven by surgery.
• Mucosal inflammation, specifically eosinophilia, is linked to osteitis but doesn't solely determine its incidence.
• Postoperative corticosteroid therapy may be beneficial for patients with osteitis to prevent recurrence.