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Updated: Mar 30, 2026
Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
Published on: June 5, 2019
A method for mapping regional oxygen and CO2 transfer in the lung
Troels Johansen1, Tilo Winkler2, Vanessa Jane Kelly2
1Department of Respiratory Diseases, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA.
This study introduces 3D maps to visualize regional lung function, showing oxygen (O2) and carbon dioxide (CO2) transfer rates. These maps enhance understanding of gas exchange in health and disease.
Area of Science:
- Pulmonary Physiology
- Medical Imaging
- Quantitative Analysis
Background:
- Regional lung function assessment is crucial for understanding gas exchange.
- Current methods may lack detailed regional resolution for O2 and CO2 transfer.
- Visualizing regional differences in gas transfer can improve diagnostic capabilities.
Purpose of the Study:
- To present a novel algorithm for generating quantitative three-dimensional maps of regional O2 and CO2 transfer rates.
- To visualize and compare regional gas exchange contributions in healthy and diseased lungs.
- To evaluate the potential of these maps as a presurgical tool and for understanding pulmonary diseases.
Main Methods:
- Development of an algorithm to create 3D maps of O2 and CO2 transfer rates.
- Utilizing Positron Emission Tomography/Computed Tomography (PET/CT) for imaging ventilation and perfusion.
- Generating regional gas transfer maps for a healthy subject and an asthmatic patient post-bronchoprovocation.
Main Results:
- Successfully generated 3D quantitative maps illustrating regional O2 and CO2 transfer rates.
- Demonstrated regional variations in gas transfer rates between O2 and CO2.
- Sensitivity analysis indicated minor impact from imaging noise and moderate sensitivity to global input value errors.
Conclusions:
- 3D gas transfer maps provide an intuitive visualization of regional lung function.
- These maps offer potential for improved understanding of pulmonary gas exchange in health and disease.
- The technique may serve as a valuable presurgical evaluation tool for lung function.
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