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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

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[Is Parkinson's disease a prion disease?]

J-P Brandel1, A-G Corbillé2, P Derkinderen2

  • 1Inserm U 1127, CNRS UMR 7225, Sorbonne universités, UPMC University Paris 06 UMR S 1127, institut du cerveau et de la mœlle épinière, ICM, 75013 Paris, France; Cellule nationale de référence des maladies de Creutzfeldt-Jakob, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Centre national de référence des agents transmissibles non conventionnels, 75013 Paris, France; Unité James-Parkinson, Fondation ophtalmologique Rothschild, 75019 Paris, France.

Revue Neurologique
|November 14, 2015
PubMed
Summary

Parkinson's disease involves the aggregation of alpha-synuclein (α-synuclein) proteins, exhibiting prion-like characteristics for propagation. Current research suggests no human transmission risk despite disease spread mechanisms.

Keywords:
Maladie de ParkinsonParkinson's diseasePrion-likeα-Synuclein

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