Association study of apolipoprotein E promoter polymorphism (-427 T/C) and Alzheimer's disease in a Tunisian
A Achouri-Rassas1, N Ben Ali2, S Fray2
1Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia; Biochemistry and molecular biology laboratory, Children's hospital, Bab Saadoun, 1029 Tunis, Tunisia.
Background:
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an as yet poorly understood etiology. Both environmental and genetic factors have been implicated as predisposing factors. The apolipoprotein E (APOE) ɛ4 allele is an established genetic susceptibility factor for AD for several populations including the Tunisian population. Polymorphism rs769446 (-427 T/C) at the promoter region of the APOE gene is postulated to affect the expression of the gene through differential binding of transcription factors.
Aims:
This study aims at examining the APOE promoter polymorphism rs769446 for possible association with AD in a Tunisian population.
Methods:
Using a case-control study design, a sample of 85 patients and 90 controls were investigated for association with the rs769446 polymorphism.
Results:
No evidence of association was found in this population upon comparison between patients and healthy controls or upon stratification by APOE ɛ4.
Conclusions:
Investigations of potential gene-gene and gene-environmental interactions for this polymorphism need to be further conducted.
More Related Videos
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
09:45Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
Related Concept Videos
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
01:26Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
01:22Alzheimer's Disease: Treatment