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Atypical CML with massive splenic infarct: an extremely rare presentation
Dhrubajyoti Bandyopadhyay1, Satyaki Manna2, Adrija Hajra2
1Department of Accident & Emergency, Lady Hardinge Medical College, Hooghly, West Bengal, India.
A rare form of chronic myeloid leukemia (CML) was diagnosed in a man with enlarged spleen and anemia. This case is the first to show CML presenting with a massive splenic infarct.
Area of Science:
- Hematology
- Oncology
- Internal Medicine
Background:
- Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
- Mixed myelodysplastic/myeloproliferative neoplasms represent a rare subtype of myeloid malignancies.
- Splenic infarction is an uncommon complication in hematological disorders.
Observation:
- A 47-year-old male presented with hepatosplenomegaly, anemia, and a massive splenic infarct.
- Diagnostic investigations were performed to elucidate the underlying cause of the patient's symptoms.
Findings:
- The patient was diagnosed with atypical chronic myeloid leukemia (aCML).
- This represents a rare variant of mixed myelodysplastic/myeloproliferative neoplasm.
- The presentation with massive splenic infarction is unique for aCML.
Implications:
- This case highlights the importance of considering aCML in patients with unexplained hepatosplenomegaly and splenic infarction.
- Early diagnosis and appropriate management of aCML are crucial for patient outcomes.
- Further research into the pathogenesis and clinical manifestations of aCML is warranted.
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