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Related Concept Videos

Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Related Experiment Video

Updated: Mar 30, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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Entorhinal Cortex Thickness across the Human Lifespan.

Khader M Hasan1, Benson Mwangi2, Bo Cao2

  • 1Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center, Houston, TX.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|November 14, 2015
PubMed
Summary

Human entorhinal cortex (ERC) thickness grows through middle age and then declines. This study quantifies ERC thickness across the lifespan in 1,660 healthy individuals, revealing age-related changes and sex differences in healthy aging.

Keywords:
Big dataFreeSurferMRIcortical thicknessentorhinal cortexlifespan

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Area of Science:

  • Neuroimaging
  • Human Anatomy
  • Lifespan Development

Background:

  • The entorhinal cortex (ERC) is crucial for memory and navigation, connecting the temporal neocortex with the hippocampus.
  • Quantitative MRI studies on ERC geometric measurements across the lifespan, particularly in pediatric and adult healthy subjects, are limited.
  • This study addresses the knowledge gap by examining ERC thickness across a wide age range.

Purpose of the Study:

  • To quantify the entorhinal cortex (ERC) thickness in a large cohort of healthy individuals spanning nine decades of life.
  • To analyze the lifespan trajectory of ERC thickness.
  • To identify potential differences in ERC thickness related to age, sex, and hemispheric asymmetry.

Main Methods:

  • Magnetic resonance imaging (MRI) data from multiple centers and a large cohort of 1,660 healthy controls (ages 2-94) were analyzed.
  • Lifespan trajectory of ERC thickness was quantified using high spatial resolution brain MRI data.
  • Statistical analyses were performed to assess age, sex, and hemispheric effects on ERC thickness.

Main Results:

  • Entorhinal cortex (ERC) thickness increased with age, peaking around 44 years, followed by a decrease.
  • ERC thickness exhibited rightward hemispheric asymmetry, with no significant gender differences observed overall.
  • Mean ERC thickness ranged from 2.943 ± .438 mm to 3.525 ± .355 mm across age groups, with a more pronounced loss noted in aging men.

Conclusions:

  • This study provides crucial data on entorhinal cortex (ERC) thickness across the human lifespan using high-resolution MRI.
  • The findings offer insights into normative aging of the ERC and may serve as a reference for future research.
  • Understanding these normative changes is vital for investigating neurological pathologies associated with cognitive decline.