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Related Experiment Videos

Persistent 5th aortic arch--a great pretender: three new covert cases.

L M Gerlis1, S Y Ho, R H Anderson

  • 1Department of Paediatrics, Brompton Hospital, London, U.K.

International Journal of Cardiology
|May 1, 1989
PubMed
Summary

Persistence of the embryonic fifth aortic arch may be underdiagnosed. This rare congenital malformation can mimic other cardiac conditions, suggesting it may go unrecognized more often than believed.

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Area of Science:

  • Cardiovascular Medicine
  • Developmental Biology
  • Congenital Malformations

Background:

  • Persistence of the embryonic fifth aortic arch is a rare congenital cardiovascular malformation.
  • Its true incidence may be underestimated due to potential misdiagnosis.

Observation:

  • Analysis of 2000 cardiopathological specimens revealed an incidence of 1 in 330.
  • Only 13 additional cases are documented in the literature.
  • Three of the identified cases were initially misinterpreted.

Findings:

  • The study details three cases of persistent fifth aortic arch.
  • Case 1: A conduit between pulmonary and systemic circulations in aortic atresia.
  • Case 2: An accessory systemic-to-systemic conduit in a double lumen aortic arch.

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  • Case 3: An aortic to pulmonary conduit initially mistaken for an aorto-pulmonary window.

    • Implications:

    • The persistent fifth aortic arch exhibits significant mimicry, potentially leading to underdiagnosis.
    • Increased awareness and diagnostic vigilance are crucial for recognizing this malformation.
    • Further research is needed to elucidate the full spectrum and incidence of this condition.