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Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Peter Belenky1, Jonathan D Ye2, Caroline B M Porter3

  • 1Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, 36 Cummington Mall, Boston, MA 02215, USA; Department of Molecular Microbiology and Immunology, Brown University, 171 Meeting Street, Providence, RI 02912, USA.

Cell Reports
|November 14, 2015
PubMed

Keywords:
E. coli, metabolomicsantibioticsdouble-strand breakslipid peroxidationoxidative stressprotein carbonylation DNA damagereactive oxygen species

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