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Effects of Atorvastatin on Serum High-Sensitive C-Reactive Protein and Total Cholesterol Levels in Asian Patients

Jing Wang1, Ai-Rong Wang, Ming-Juan Zhang

  • 11Renal Department of Internal Medicine, Haiyang People's Hospital, Haiyang 265100, P. R. China; and 2Department of Internal Medicine, Weihai Municipal Hospital, Weihai, P. R. China.

American Journal of Therapeutics
|November 14, 2015
PubMed

Insights

Atorvastatin treatment significantly reduced high-sensitive C-reactive protein (hs-CRP) and total cholesterol (TC) levels in atrial fibrillation (AF) patients. This led to a lower AF recurrence rate compared to standard treatment.

Area of Science:

  • Cardiology and Cardiovascular Research
  • Pharmacology and Therapeutics
  • Biomarkers and Disease Management

Background:

  • Elevated serum high-sensitive C-reactive protein (hs-CRP) and total cholesterol (TC) are linked to atherosclerotic vascular disease and vascular events.
  • Atrial fibrillation (AF) recurrence is a significant clinical concern, often associated with underlying cardiovascular risk factors.

Purpose of the Study:

  • To evaluate the impact of atorvastatin treatment on serum hs-CRP and TC levels in patients with AF.
  • To assess the effect of atorvastatin on the recurrence rate of AF.
  • To confirm findings through a comprehensive meta-analysis.

Main Methods:

  • A prospective study involving 105 AF patients: 55 treated with amiodarone and atorvastatin, 50 with amiodarone alone (control).
  • Patients were treated for 12 months with regular follow-up for 1 year.
  • Serum hs-CRP and TC levels were measured pre- and post-treatment; AF recurrence was recorded at 3, 6, and 12 months. A meta-analysis of 13 studies was also conducted.

Main Results:

  • After 12 months, the atorvastatin group showed significantly reduced serum hs-CRP (3.63 ± 2.14 mg/L vs. 2.75 ± 1.89 mg/L) and TC levels (4.66 ± 1.13 mmol/L vs. 4.20 ± 1.06 mmol/L) compared to the control group (P < 0.05 for both).
  • The AF recurrence rate was significantly lower in the atorvastatin treatment group (16.4%) versus the control group (34.0%) (P = 0.037).
  • Meta-analysis confirmed significant reductions in hs-CRP (SMD = 0.95, P < 0.001) and TC (SMD = 1.39, P < 0.001) with atorvastatin treatment.

Conclusions:

  • Atorvastatin treatment is effective in lowering serum hs-CRP and TC levels in patients with AF.
  • Atorvastatin significantly reduces the recurrence rate of AF.
  • These findings support the use of atorvastatin as an adjunctive therapy for AF management, particularly in patients with elevated inflammatory and lipid markers.

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