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Related Concept Videos

Theorem of Pappus01:24

Theorem of Pappus

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The Theorem of Pappus, also known as the Pappus–Guldinus Theorem, provides a geometric method for determining the volume and surface area of solids generated by the revolution of a plane region or a plane curve about an external axis. The theorem consists of two related statements. The first addresses the volume of solids formed by rotating plane areas, while the second addresses the surface area generated by rotating plane curves. Both results depend on the location of the centroid,...
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Parseval's Theorem01:18

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Parseval's theorem is a fundamental concept in signal processing and harmonic analysis. It asserts that for a periodic function, the average power of the signal over one period equals the sum of the squared magnitudes of all its complex Fourier coefficients. This theorem, named after Marc-Antoine Parseval, provides a powerful tool for analyzing the energy distribution in signals.
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Pappus and Guldinus's theorems are powerful mathematical principles that are used for finding the surface area and volume of composite shapes. For example, consider a cylindrical storage tank with a conical top. Finding the surface area or volume can be challenging for such complex shapes. These theorems are particularly useful in calculating the volume and surface area of such systems. Here, the cylindrical storage tank with a conical top can be broken down into two simple shapes: a...
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Consider a region consisting of several individual conductors with a definite charge density in the region between these conductors. The second uniqueness theorem states that if the total charge on each conductor and the charge density in the in-between region are known, then the electric field can be uniquely determined.
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Sampling Theorem01:15

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A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
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Response to Pick.

Vincent Jaquet1, A Richard Rutter2

  • 11 Department of Pathology and Immunology, Geneva Medical Faculty, Geneva University Hospitals , Centre Médical Universitaire, Geneva, Switzerland .

Antioxidants & Redox Signaling
|November 15, 2015
PubMed
Summary
This summary is machine-generated.

This study clarifies the inhibitory action of GSK2795039 on NOX2. New experiments confirm GSK2795039 effectively inhibits the NOX2 isoform in the submicromolar range.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Cellular Biology

Background:

  • Concerns were raised regarding the representation of NOX2 inhibitory data for GSK2795039.
  • Relative values were initially used to describe the inhibitory action of the small molecule.

Purpose of the Study:

  • To address criticisms regarding the use of relative values in NOX2 inhibition assays.
  • To provide absolute turnover values for the NOX2 inhibitory action of GSK2795039.

Main Methods:

  • Performed additional superoxide inhibitable assays: cytochrome C and water-soluble tetrazolium salt (WST-1) reduction.
  • Utilized a semi-recombinant NOX2 membrane assay.

Main Results:

  • Documented turnover values between 80 and 100 mol O2(•-)/s/mol cytochrome b558.
  • Confirmed that GSK2795039 inhibits the NOX2 isoform within the submicromolar concentration range.

Conclusions:

  • The study provides definitive turnover values for NOX2 inhibition by GSK2795039.
  • GSK2795039 demonstrates potent inhibition of the NOX2 isoform, validating its therapeutic potential.