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Updated: Mar 30, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Four key questions surrounding thrombolytic therapy for submassive pulmonary embolism
Akhilesh K Sista1, James M Horowitz2, Samuel Z Goldhaber3
1Weill Cornell Medical College, New York, NY, USA aks9010@med.cornell.edu.
Abstract:
Submassive pulmonary embolism (PE) remains a vexing entity, and the appropriate use of thrombolytic therapy for this subgroup continues to be actively debated. Catheter-directed thrombolysis has shown efficacy for submassive PE and is gaining momentum because of theoretically improved safety. This review poses and responds to four questions that explore the complex issues surrounding optimal therapy of submassive PE.
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