Extraversion modulates functional connectivity hubs of resting-state brain networks

Area of Science:

• Neuroscience
• Psychology
• Brain Imaging

Background:

• Extraversion, a personality dimension, relates to social behavior and emotional functioning.
• Brain's intrinsic functional connectivity patterns are reportedly linked to extraversion.
• The association between extraversion and functional brain hubs requires further investigation.

Purpose of the Study:

• To investigate the neurobiological underpinnings of extraversion using functional connectivity density (FCD).
• To identify specific brain hubs and functional connectivity patterns associated with extraversion.

Main Methods:

• Utilized resting-state functional magnetic resonance imaging (fMRI) data from 71 healthy subjects.
• Employed the functional connectivity density (FCD) method to analyze brain activity.
• Conducted seed-based resting-state functional connectivity (RSFC) analyses.

Main Results:

• Short-range FCD positively correlated with extraversion in the left cuneus, linking local activity to risk-taking.
• Long-range FCD negatively correlated with extraversion in the right superior frontal and inferior frontal gyri.
• High extraversion scores were associated with decreased long-range functional connectivity between prefrontal cortex regions, middle temporal gyrus, and anterior cingulate cortex.

Conclusions:

• Specific brain hubs and long-range functional connections are associated with extraversion.
• Findings suggest decreased RSFC patterns may modulate self-esteem, self-evaluation, and inhibitory control in extraversion.
• This study provides a neurobiological basis for understanding the personality dimension of extraversion.