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1Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, QC H3T 1J4, Canada.
Abstract:
HIV commonly escapes host antiviral immunity by downregulating cell-surface immunoreceptors. In a recent issue of Cell Host & Microbe, Matheson et al. (2015) systematically examined how HIV-1 infection remodels the T cell surface and identified serine carriers SERINC3/5 and alanine transporter SNAT1 as targets of HIV-1 Nef and Vpu, respectively.
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