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Evaluation of platelet distribution width in chronic obstructive pulmonary disease patients with pulmonary embolism

Maofeng Wang^1,2, Jun Zhang¹, Qiaoying Ji³

¹Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310000, China.

Biomarkers in Medicine

|November 17, 2015

Abstract

Background:

Platelets play an important role in the pathogenesis of pulmonary embolism (PE). We aimed to investigate whether there is a correlation between platelet distribution width (PDW) and chronic obstructive pulmonary disease (COPD) patients with PE.

Methods:

We conducted a retrospective study using 126 COPD patients with PE and 51 COPD patients without PE. Blood biomarkers, including PDW and d-dimer, were included. Odds ratios (OR) associated with PDW and interactions with d-dimer, SpO2 were estimated for PE.

Results:

PDW was higher in the COPD patients with PE group (p = 0.007). A higher PDW had a significantly increased risk of PE than a lower PDW (adjusted OR 2.724, 95% CI: 1.290-5.753).

Conclusion:

PDW are elevated in COPD patients with PE and are associated with the risk of PE.

Keywords:

chronic obstructive pulmonary disease platelet distribution width pulmonary embolism

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