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Current status and future perspectives of fluorescence-guided surgery for cancer

Jonathan C DeLong1, Robert M Hoffman1,2, Michael Bouvet1

  • 1a Department of Surgery , University of California San Diego , San Diego , CA , USA.

Expert Review of Anticancer Therapy
|November 17, 2015
PubMed

Insights

Fluorescence-guided surgery (FGS) illuminates cancer cells for improved detection and removal during operations. This technique offers enhanced precision over traditional methods, aiding surgeons in achieving complete tumor resection.

Area of Science:

  • Oncology
  • Surgical Innovation
  • Medical Imaging

Background:

  • Complete removal of cancerous cells is crucial for curative cancer surgery.
  • Current methods for tumor detection and margin assessment lack sensitivity and can be subjective.
  • Fluorescence-guided surgery (FGS) offers a promising approach to overcome these limitations.

Purpose of the Study:

  • To review the preclinical developments and current techniques of fluorescence-guided surgery (FGS).
  • To highlight the potential of FGS in improving cancer surgery outcomes.

Main Methods:

  • Review of existing literature on fluorescence-guided surgery.
  • Description of preclinical advancements and currently utilized FGS techniques.
  • Analysis of FGS's role in tumor detection, navigation, and margin confirmation.

Main Results:

  • FGS techniques selectively illuminate cancer cells, improving the distinction between tumors and healthy tissues.
  • The potential for single-cell sensitivity in FGS enhances detection capabilities.
  • FGS improves tumor detection, surgical navigation, and margin confirmation.

Conclusions:

  • Fluorescence-guided surgery represents an emerging technology with the potential to significantly improve the efficacy of cancer surgery.
  • FGS can aid in the complete removal of both primary and metastatic cancer cells.
  • Further development and application of FGS techniques are expected to enhance surgical precision and patient outcomes.
Keywords:
Fluorescence-guided surgery (FGS)fluorescent proteinsfluorophorephotoimmunotherapytheranostics

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