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Updated: Mar 30, 2026

Fluorescence-Based Detection of FEN1 Nuclease Activity and Screening of Small-Molecule Inhibitors
Published on: June 27, 2025
Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors
Fang-Yuan Cao, Xiao-Ping Zhou1, Jing Su2
1Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Jilin University, No.1266 Fujin Road, Changchun, 130021, China.
Abstract:
Focal adhesion kinase (FAK) is a non-receptor tryosine kinase that plays a vital role in tumor cell survival, proliferation and migration. It has been shown that inhibiting the activity of FAK may result in impeding tumor cells invasion and growth. There are several small molecule FAK inhibitors which have been developed with outstanding FAK inhibitory activity. And most of the small molecules are nitrogen-containing aromatic compounds. This review describes the chemical structure characteristics and activity of current small molecule FAK inhibitors that aims to serve as a future reference for the development of potential FAK inhibitors.
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