BNP and NT-proBNP elevation after running--a systematic review
Running can temporarily elevate levels of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) beyond normal ranges in a significant portion of individuals. These findings suggest careful interpretation of cardiac biomarker levels post-exercise.
Area of Science:
- Exercise Physiology
- Cardiovascular Biomarkers
- Sports Medicine
Background:
- B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are cardiac biomarkers.
- Elevated levels can indicate cardiac stress or dysfunction.
Purpose of the Study:
- To systematically review the pattern of BNP and NT-proBNP release following running.
- To analyze post-exercise biomarker levels in runners.
Main Methods:
- Systematic review of scientific literature.
- Searched PubMed, ISI Web of Knowledge, and Scopus databases.
- Included 53 relevant reports, with 27 providing quantitative data.
Main Results:
- Analyzed data from 1,034 participants.
- 22.9% of runners showed elevated BNP levels post-exercise.
- 35.9% of runners showed elevated NT-proBNP levels post-exercise.
Conclusions:
- Post-running BNP and NT-proBNP levels can exceed upper reference limits in a substantial percentage of runners.
- Findings highlight the need to consider exercise as a factor when interpreting these biomarkers.
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