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Updated: Mar 30, 2026
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
Published on: February 23, 2024
Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools
Vincenzo Abbate1, Olivier Reelfs2, Xiaole Kong1
1Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. robert.hider@kcl.ac.uk.
Abstract:
Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.
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