α-Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358
Wei-Guang Shan1, Zhao-Ying Wu1, Wei-Wei Pang1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
Abstract:
One new diketopiperazine alkaloid amauromine B (1), along with three known meroterpenoids, austalide B (2), austalides N and O (3 and 4), and two known steroids (5 and 6), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D-NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X-ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on α-glucosidase. Amauromine B (1) and austalide N (3) exhibited more potent α-glucosidase inhibitory activities than the positive control acarbose.
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