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Related Concept Videos

Enzyme Inhibition01:30

Enzyme Inhibition

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Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Related Experiment Video

Updated: Apr 26, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
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Esterase activity in erythroleukemia.

L Kass

    American Journal of Clinical Pathology
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Specific esterase activity, usually found in granulocytes, was detected in abnormal red blood cell precursors (erythroblasts) from patients with erythroleukemia. This finding was absent in normal individuals, suggesting a potential diagnostic marker for this leukemia.

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    Area of Science:

    • Hematology
    • Cell Biology
    • Biochemistry

    Background:

    • Specific esterase activity is a characteristic enzyme marker typically associated with granulocytic cells.
    • Erythroid precursors are generally not expected to exhibit specific esterase activity.
    • Erythroleukemia is a hematological malignancy characterized by abnormal proliferation of erythroid precursors.

    Purpose of the Study:

    • To investigate the presence and significance of esterase activity in erythroid precursors from patients with erythroleukemia.
    • To determine if specific esterase activity is a distinguishing feature of abnormal erythroblasts in this condition.

    Main Methods:

    • Bone marrow aspirates were collected from six patients with untreated erythroleukemia and ten healthy individuals.
    • Histochemical staining techniques were employed to detect both specific and nonspecific esterase activity in erythroid precursors (erythroblasts).

    Main Results:

    • Abnormal erythroid precursors from erythroleukemia patients exhibited significant specific esterase activity.
    • These abnormal erythroblasts also showed nonspecific esterase activity.
    • No specific or nonspecific esterase activity was detected in erythroid precursors from normal individuals.

    Conclusions:

    • The presence of specific esterase activity in erythroblasts is an abnormal finding associated with erythroleukemia.
    • This enzymatic activity may serve as a potential diagnostic indicator for erythroleukemia.
    • Further research is warranted to elucidate the precise role and implications of specific esterase activity in erythroleukemia pathogenesis.