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[Antioxidants--antioxidative stress: facts and questions, 2015]

Krisztina Hagymási1, Anna Egresi1, Gabriella Lengyel1

  • 1II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.

Orvosi Hetilap
|November 17, 2015
PubMed

Insights

Antioxidant therapy shows potential for oxidative stress disorders but can have adverse effects. Combining antioxidants may offer more benefits than single supplements.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Cell Biology

Context:

  • Oxidative stress is implicated in numerous diseases.
  • Antioxidant therapies have been widely investigated for prevention and treatment.
  • Previous studies and meta-analyses yielded mixed results regarding antioxidant efficacy.

Purpose:

  • To review the prooxidant effects of antioxidants.
  • To explore the role of antioxidants in cellular signaling and process modulation.
  • To summarize potential benefits of combined antioxidant use.

Summary:

  • While initially promising, antioxidant therapy has shown undesirable side effects, including toxicity and prooxidant effects.
  • Large-scale studies and meta-analyses have not confirmed the benefits of antioxidant supplementation for primary or secondary prevention.
  • The review discusses how antioxidants influence cell signaling and modulate cellular processes, suggesting combined use may be more favorable.

Impact:

  • Highlights the complex role of antioxidants beyond simple free radical scavenging.
  • Provides insights into potential risks and limitations of antioxidant supplementation.
  • Suggests a paradigm shift towards understanding combined antioxidant strategies for therapeutic applications.
Keywords:
antioxidant vitaminsantioxidative stressantioxidáns vitaminokantioxidánsstresszcell signallingjelátviteli folyamatokoxidative stressoxidatív stresszprooxidantprooxidáns

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