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[The role of oxidative stress in heart failure]

Roland Gál1, Róbert Halmosi1

  • 1I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Ifjúság útja 13., 7624.

Orvosi Hetilap
|November 17, 2015
PubMed

Insights

Oxidative stress contributes to heart failure by damaging heart cells and blood vessels. This damage involves reactive oxygen species from various sources, leading to cellular changes and cardiac remodeling.

Area of Science:

  • Cardiology
  • Biochemistry
  • Molecular Biology

Context:

  • Oxidative stress is increasingly recognized as a key factor in the pathogenesis of heart failure.
  • Reactive oxygen and nitrogen species are produced by multiple cellular sources within the myocardium.

Purpose:

  • To elucidate the role of oxidative stress in the development of heart failure.
  • To identify the sources and consequences of reactive oxygen and nitrogen species in cardiac tissue.

Summary:

  • Oxidative stress, mediated by reactive oxygen species (ROS) from sources like NADPH oxidases and mitochondria, damages myocardial cells.
  • ROS contribute to vascular dysfunction (endothelial dysfunction, atherosclerosis) and cardiac remodeling.
  • Oxidative stress induces lipid peroxidation, protein oxidation, DNA damage, and alters signaling pathways crucial for cardiac hypertrophy and dilation.

Impact:

  • Understanding the mechanisms of oxidative stress in heart failure can guide therapeutic strategies.
  • Identifying ROS sources may lead to targeted interventions to prevent or treat cardiac dysfunction.
  • This research highlights the critical link between oxidative damage and the progression of heart failure.
Keywords:
heart failureoxidative stressoxidatív stresszreactive oxygen speciesreaktívoxigén-származékokremodelingremodellingszívelégtelenség

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