Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

miR-489 induces immunogenic cell death in breast cancer by targeting LAPTM4B.

Frontiers in oncology·2026
Same author

Amorphous Ru-bda MCOF: A Frontier in Heterogeneous Molecular Catalysis for Water Oxidation.

Inorganic chemistry·2026
Same author

Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1.

Nature communications·2026
Same author

MicroDiffuse3D: A Foundation Model for 3D Microscopy Imaging Restoration.

ArXiv·2026
Same author

Chemical composition imaging and class imbalance handling using a 2D-CNN with SMOTE and threshold moving for tobacco origin classification.

Talanta·2026
Same author

Precise Microstructural and Stoichiometric Control Advances Flexible Ag<sub>2</sub>Te Thin-Film Thermoelectrics for Wearable Energy Harvesting.

Advanced materials (Deerfield Beach, Fla.)·2026

Related Experiment Video

Updated: Mar 30, 2026

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
08:22

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

639

Cancer cell-selective killing polymer/copper combination.

Huacheng He1, Diego Altomare1, Ufuk Ozer2

  • 1Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC 29208, USA. xup@sccp.sc.edu.

Biomaterials Science
|November 17, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a novel polymer-copper combination therapy that effectively targets and eliminates multidrug-resistant cancer cells while sparing healthy cells. The therapy leverages cancer cells' high glutathione levels for enhanced efficacy and selectivity.

More Related Videos

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.6K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Related Experiment Videos

Last Updated: Mar 30, 2026

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
08:22

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

639
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.6K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Chemotherapy faces challenges in cancer treatment due to multidrug resistance and poor selectivity.
  • Developing targeted therapies that overcome resistance and spare normal cells is crucial.

Purpose of the Study:

  • To develop a novel polymer-copper nanoparticle system for effective cancer cell killing.
  • To enhance selectivity towards cancer cells, including drug-resistant types, while sparing normal cells.

Main Methods:

  • A pyridine-2-thiol containing polymer nanoparticle was combined with copper.
  • Cellular uptake was facilitated via an exofacial thiol route, releasing active pyridine-2-thiol triggered by intracellular glutathione (GSH).
  • RNA microarray analysis was performed to investigate gene expression changes.

Main Results:

  • The polymer-copper combination effectively killed a wide spectrum of cancer cells, including drug-resistant ones.
  • Normal cells were spared, indicating high selectivity.
  • Treatment reversed upregulated oncogenes (CIRBP, STMN1) and downregulated tumor suppressor genes (CDKN1C, GADD45B) in cancer cells.

Conclusions:

  • The polymer/copper nanoparticle system demonstrates significant potential as a selective and effective cancer therapeutic.
  • The therapy's efficacy is enhanced in cancer cells due to their elevated GSH levels.
  • The observed gene expression modulation further supports the targeted action against cancer cells.