Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.5K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.5K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.4K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.4K
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

6.5K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
6.5K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

1.4K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
1.4K
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.9K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.9K
Drug Classes and Categories01:25

Drug Classes and Categories

3.4K
Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From purity to proportionality: managing nonfinancial conflicts of interest in pain medicine.

Pain medicine (Malden, Mass.)·2026
Same author

Long-Term Pain Therapy With Opioids.

JAMA·2025
Same author

The impact of medication adherence on health outcomes and cost reduction.

Journal of opioid management·2025
Same author

Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis.

Pain medicine (Malden, Mass.)·2022
Same author

Drug trafficking, good faith, and legal standards to convict: How the United States Supreme Court is about to affect every prescriber in America.

Journal of opioid management·2022
Same author

Pharmacokinetics of Buprenorphine Buccal Film and Orally-administered Oxycodone in a Respiratory Study: An Analysis of Secondary Outcomes from a Randomized Controlled Trial.

Pain and therapy·2022

Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

3.0K

Current Regulations Related to Opioid Prescribing.

Lynn R Webster1, Martin Grabois2

  • 1PRA Health Sciences, 3838 South 700 East, Suite 202, Salt Lake City, UT 84106.

PM & R : the Journal of Injury, Function, and Rehabilitation
|November 17, 2015
PubMed
Summary
This summary is machine-generated.

Physicians must stay updated on opioid prescribing laws to ensure patient safety and avoid legal issues. Compliance with regulations is crucial for safe pain management and preventing opioid-related harm.

More Related Videos

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

3.4K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.8K

Related Experiment Videos

Last Updated: Mar 30, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

3.0K
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

3.4K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.8K

Area of Science:

  • Medical Law
  • Public Health Policy
  • Pain Management

Background:

  • Opioids are commonly prescribed for pain relief but carry risks of misuse, addiction, and overdose.
  • Strict regulations govern opioid prescribing due to significant public health concerns.
  • Healthcare providers need current information on laws and guidelines to ensure safe and compliant opioid prescribing.

Purpose of the Study:

  • To provide an overview of the legal and regulatory framework for controlled substances.
  • To discuss federal and state actions aimed at mitigating opioid-related harm.
  • To emphasize the importance of compliance for prescribers.

Main Methods:

  • Review of federal and state laws and regulations concerning opioid prescribing.
  • Analysis of current treatment guidelines and regulatory actions.
  • Discussion of compliance strategies for healthcare providers.

Main Results:

  • An increasing number of opioid-prescribing policies are being implemented by governments.
  • Failure to comply with opioid laws can lead to legal and regulatory sanctions.
  • Essential compliance actions include documentation, patient risk assessment, and utilizing tools like prescription monitoring databases and urine drug screening.

Conclusions:

  • Adherence to evolving opioid prescribing laws and guidelines is essential for medical professionals.
  • Proactive compliance measures are necessary to prevent opioid-related harm and ensure patient safety.
  • Understanding the legal landscape is critical for responsible pain management and avoiding sanctions.