Related Experiment Video

Updated: Mar 30, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

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Novel Targeted Agents in Head and Neck Squamous Cell Carcinoma

Pedro H Isaacsson Velho1, Gilberto Castro1, Christine H Chung2

  • 1Department of Clinical Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Hematology/Oncology Clinics of North America
|November 17, 2015
PubMed

Insights

Genomic analysis reveals limited actionable targets in head and neck squamous cell carcinoma, hindering immediate treatment translation. Further research is crucial for developing effective therapies and biomarkers for this challenging cancer.

Area of Science:

  • Oncology
  • Genomics
  • Translational Medicine

Background:

  • Head and neck squamous cell carcinoma (HNSCC) presents significant challenges due to a scarcity of targetable genomic alterations.
  • Current genomic data suggests limited opportunities for direct clinical translation of targeted therapies in HNSCC.

Purpose of the Study:

  • To review potential therapeutic agents for HNSCC based on compelling scientific rationales.
  • To highlight the need for improved predictive biomarkers and therapeutic strategies in HNSCC treatment.

Main Methods:

  • Review of current genomic data in HNSCC.
  • Evaluation of potential therapeutic agents with strong scientific backing.
  • Discussion of challenges in clinical translation and biomarker development.

Main Results:

  • Most HNSCC cases exhibit few targetable genomic aberrations.
  • Several potential therapeutic agents warrant thorough investigation for HNSCC.
  • Identifying predictive biomarkers and optimizing therapeutic strategies remain critical.

Conclusions:

  • Despite limited targetable aberrations, promising therapeutic avenues exist for HNSCC.
  • Advancements require better biomarkers, understanding of resistance, and innovative clinical trials.
  • A concerted effort is needed to improve treatment outcomes for head and neck squamous cell carcinoma.
Keywords:
AngiogenesisAxlCell cycle regulationDNA damage responseFGFRNOTCHPI3K/mTORc-MET

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