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Related Concept Videos

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

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The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
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Exocrine Glands: Types of Secretions01:13

Exocrine Glands: Types of Secretions

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Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

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Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
33.8K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
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Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research

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Salivary Gland Malignancies.

Cristina P Rodriguez1, Upendra Parvathaneni2, Eduardo Méndez3

  • 1Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Avenue East, MS G4940, Seattle, WA 98109, USA.

Hematology/Oncology Clinics of North America
|November 17, 2015
PubMed
Summary

Research on rare salivary gland cancers is difficult, but new treatments like targeted therapies and immunotherapies show promise for improving patient care.

Keywords:
ManagementReviewSalivary cancerSystemicTherapy

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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
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Area of Science:

  • Oncology
  • Head and Neck Surgery

Background:

  • Salivary gland malignant tumors are rare and diverse neoplasms.
  • Limited research data necessitates reliance on case reviews and small trials for therapeutic guidance.

Purpose of the Study:

  • To summarize current therapeutic strategies for salivary gland malignant tumors.
  • To highlight emerging treatment modalities and their potential impact.

Main Methods:

  • Review of existing literature and clinical trial data.
  • Analysis of standard treatment protocols including surgery and radiotherapy.
  • Evaluation of systemic therapies for metastatic disease.

Main Results:

  • Surgical resection is the standard for localized disease.
  • Radiotherapy is crucial when surgery is contraindicated or associated with morbidity.
  • Systemic therapy is reserved for symptomatic metastatic disease.

Conclusions:

  • Despite challenges in research due to low incidence, advancements in cooperative group trials, molecularly targeted treatments, and immunotherapies offer hope for improved outcomes.
  • Multidisciplinary approaches integrating surgery, radiotherapy, and novel systemic agents are essential for managing these complex tumors.