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Updated: Mar 30, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
Published on: January 26, 2024
MIEC-SVM: automated pipeline for protein peptide/ligand interaction prediction
Nan Li1, Richard I Ainsworth1, Meixin Wu1
1Department of Chemistry and Biochemistry, UC, San Diego, La Jolla, CA 92093-0359 USA.
Motivation:
MIEC-SVM is a structure-based method for predicting protein recognition specificity. Here, we present an automated MIEC-SVM pipeline providing an integrated and user-friendly workflow for construction and application of the MIEC-SVM models. This pipeline can handle standard amino acids and those with post-translational modifications (PTMs) or small molecules. Moreover, multi-threading and support to Sun Grid Engine (SGE) are implemented to significantly boost the computational efficiency.
Availability And Implementation:
The program is available at http://wanglab.ucsd.edu/MIEC-SVM CONTACT: : wei-wang@ucsd.edu
Supplementary Information:
Supplementary data available at Bioinformatics online.
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