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Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population

Siang Ing Lee1, Mitesh Patel1, Christopher M Jones1

  • 1School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK.

Therapeutic Advances in Chronic Disease
|November 17, 2015
PubMed

Insights

Cardiovascular disease (CVD) poses a significant threat to individuals with type 1 diabetes mellitus (T1D). Current management strategies lack specific evidence for T1D patients, especially older adults, highlighting an urgent need for targeted research.

Area of Science:

  • Cardiology
  • Endocrinology
  • Geriatrics

Background:

  • Cardiovascular disease (CVD) is a primary cause of death in type 1 diabetes mellitus (T1D).
  • Existing research often extrapolates data from type 2 diabetes (T2D) or the general population, overlooking critical differences in T1D pathology and demographics.
  • Increasing life expectancy exposes T1D patients to age-related cardiovascular (CV) risk factors.

Purpose of the Study:

  • To review the current literature on CVD in T1D patients.
  • To assess CVD prevalence, risk management, and potential biomarkers specifically within the T1D population.
  • To evaluate the inclusion of older T1D patients (aged >65) in existing studies and discuss their CV risk management.

Main Methods:

  • Systematic literature review of studies focusing on CVD in T1D.
  • Analysis of data concerning CVD prevalence and risk factor management in T1D.
  • Examination of research including older T1D populations and their specific management strategies.

Main Results:

  • Significant CVD burden observed in T1D patients.
  • Inadequate management of CV risk factors in this population.
  • Limited evidence base for therapeutic CV risk management tailored to T1D, particularly in older adults.

Conclusions:

  • There is a substantial CVD burden in T1D patients with suboptimal risk factor management.
  • A critical gap exists in evidence-based therapeutic strategies for CVD risk in T1D, especially for the aging demographic.
  • Further research is essential to explore the risks and benefits of CVD management interventions in older T1D patients.

Keywords:
Type 1 diabetesageingcardiovascular diseaseelderlymanagementolder adultsolder agedprevalencerisk factortreatment

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