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Published on: August 15, 2025
Atypical Isolated Infections of the Infratemporal Fossa: A Diagnostic Challenge
Sien Hui Tan1, Aun Wee Chong1, Narayanan Prepageran1
1Department of Otorhinolaryngology, Faculty of Medicine, University Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia.
Introduction:
Atypical infratemporal fossa infections are rare and potentially fatal.
Case Report:
A case of an aspergillosis localized in the infratemporal fossa and another case of tuberculosis of the infratemporal fossa originating from the maxillary sinus, is described. The first patient was immunocompromised and showed symptoms of facial numbness; whereas the other was an immunocompetent man who complained of trigeminal neuralgia type pain. It was difficult to differentiate between infection and tumour despite the utilization of computed tomography scans and magnetic resonance imaging.
Conclusion:
These cases illustrate the need for a high index of suspicion; in addition to endoscopic confirmation and histopathology to establish precise diagnosis and early intervention.
Insights
Atypical infratemporal fossa infections, though rare, can be life-threatening. Early diagnosis through endoscopy and histopathology is crucial for effective treatment of these challenging infections.
Area of Science:
- Infectious diseases
- Otolaryngology
- Medical imaging
Background:
- Atypical infections of the infratemporal fossa are uncommon but carry a high risk of mortality.
- These infections can present with diverse symptoms, complicating initial diagnosis.
Observation:
- Two distinct cases are presented: an immunocompromised patient with infratemporal fossa aspergillosis and facial numbness, and an immunocompetent patient with tuberculosis of the infratemporal fossa presenting as trigeminal neuralgia.
- Both computed tomography (CT) and magnetic resonance imaging (MRI) posed challenges in differentiating between infectious processes and neoplastic conditions.
Findings:
- Aspergillosis and tuberculosis represent rare but serious causes of infratemporal fossa infections.
- Clinical presentation can mimic other pathologies, including tumors, making diagnosis difficult.
Implications:
- A high index of suspicion is essential for diagnosing rare infratemporal fossa infections.
- Endoscopic visualization and histopathological examination are critical for accurate diagnosis and timely intervention.
- Prompt diagnosis and treatment are vital for improving outcomes in patients with these potentially fatal infections.
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