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A new biflavonoid from the whole herb of Lepisorus ussuriensis
Jie Luo1,2, Wei Zhou1, Shuo Cao1
1a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
Abstract:
A new biflavonoid, 7-O-methylnaringenin-(4'→O→6″)-scutellarein (1), together with 11 known compounds (2-12) were isolated from the whole herb of Lepisorus ussuriensis. The structure of compound 1 was elucidated by spectroscopic analyses. Amongst them, dihydroquercetin (6), diosmetin (9), baicalein (11) and 7,8-dihydroxyflavone (12) were reported from the family Polypodiaceae for the first time. Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-α-induced NF-κB reporter gene expression on HeLa cells up to 30 and 100 μM.

