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Severe jaundice due to intrahepatic cholestasis after initiating anticoagulation with rivaroxaban

Abdullah N Aslan1, Cenk Sari, Serdal Baştuğ

  • 1aDepartment of Cardiology, Ankara Ataturk Education and Research Hospital bDepartment of Cardiology, Yildirim Beyazit University cDepartment of Gastroenterology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|November 17, 2015
PubMed

Rivaroxaban, a highly selective direct factor Xa inhibitor, is a new oral anticoagulant approved by the US Food and Drug Administration in November 2011 for stroke prophylaxis in patients with nonvalvular atrial fibrillation. Because of its efficacy and once-a-day dosing, it is commonly preferred in patients with nonvalvular atrial fibrillation and intolerance to warfarin in clinical practice. However, it can result in some adverse effects such as bleeding, rashes and liver injury. Here, we described a very rare adverse reaction of rivaroxaban, jaundice due to intrahepatic cholestasis, appeared in a 71-year-old male patient after taking rivaroxaban.

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