Related Experiment Videos
[Research and development of oral controlled-release dosage forms]
Journal De Pharmacie De Belgique
|January 1, 1989
Summary
Gamma scintigraphy reveals limitations in current oral sustained release dosage forms. New buoyant and polymer-based controlled release products may reduce drug plasma level variations in patients.
Area of Science:
- Pharmacokinetics and Drug Delivery
- Gastrointestinal Physiology
Context:
- Gastrointestinal transit of oral solid dosage forms is crucial for drug efficacy.
- Gamma scintigraphy provides valuable insights into drug absorption and release.
- Current oral sustained release dosage forms exhibit significant limitations.
Purpose:
- To identify the principal limitations of available oral sustained release dosage forms.
- To explore novel controlled release technologies for improved drug delivery.
Summary:
- Recent gamma scintigraphy data highlight significant challenges with existing oral sustained release formulations.
- These limitations include large inter- and intra-subject variations in drug plasma levels.
- Development of advanced dosage forms, like buoyant systems and polymer coevaporates, is proposed.
Impact:
- Potential to decrease variability in drug plasma concentrations.
- Improved therapeutic outcomes and patient compliance with oral medications.
- Advancement in the field of controlled drug delivery systems.