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Related Experiment Videos

Candidal antigenemia: a prognostic determinant.

T Suits1, G J Wise, B Walters

  • 1Division of Urology, Maimonides Medical Center, Brooklyn, New York.

The Journal of Urology
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

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A commercial assay for candidal antigenemia is useful for hospital patients with candiduria (yeast in urine). Elevated antigen titers correlate with serious infections and increased mortality, aiding in the evaluation of debilitated patients.

Area of Science:

  • Medical Mycology
  • Clinical Diagnostics
  • Infectious Diseases

Background:

  • Candiduria, yeast in the urine, is common in hospitalized patients, especially those with indwelling urinary catheters.
  • Determining the extent of Candida infection and its clinical significance in debilitated patients remains challenging.
  • Candidal antigenemia indicates systemic spread of Candida and is associated with poor outcomes.

Purpose of the Study:

  • To evaluate a commercial antibody-coated latex particle assay for detecting candidal antigenemia.
  • To assess the correlation between candidal antigen titers, candiduria, and patient outcomes.
  • To determine the diagnostic utility of candidal antigen detection in debilitated hospitalized patients.

Main Methods:

  • A commercially available antibody-coated latex particle assay was used to detect candidal antigenemia.

Related Experiment Videos

  • Ninety-eight hospitalized patients were divided into three groups: persistent Candida albicans candiduria, candiduria due to other Candida species, and no documented candiduria.
  • Patient data including urinary catheter status, positive culture sites, antigen titers, and mortality were collected and analyzed.

    • Main Results:

    • Elevated candidal antigen titers were significantly more frequent in patients with Candida albicans candiduria and other positive sites (87%) compared to those with candiduria alone (31%).
    • Patients with elevated titers and Candida albicans candiduria plus other positive sites had a 100% mortality rate, versus 63% for candiduria alone.
    • The assay demonstrated a sensitivity of 62.8%, specificity of 84%, and predictive value of 68.7% for detecting candidal antigenemia in the context of candiduria and/or multiple positive sites.

    Conclusions:

    • The commercial candidal antigen detection system is a valuable laboratory tool for evaluating debilitated patients with candiduria.
    • Elevated candidal antigen titers are associated with disseminated Candida infections and increased mortality.
    • The assay aids in risk stratification and clinical decision-making for patients with suspected invasive candidiasis.