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Updated: Mar 30, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets
Guang-Ning Yan1, Yang-Fan Lv1, Qiao-Nan Guo1
1Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Abstract:
Osteosarcoma is the most common type of bone cancer, especially in children and young adults. The primary treatment for osteosarcoma is a combination of surgery and chemotherapy, however prognoses remain poor due to chemoresistance and early metastases. Osteosarcoma stem cells appear to play central roles in tumor recurrence, metastases and chemoresistance via self-renewal and differentiation. Targeting these cells may provide a novel strategy in the treatment of osteosarcoma. This review summarizes current knowledge of this rare phenotype and recent advances in understanding the functions OSCs (osteosarcoma stem cells) in osteosarcoma, with the aim of improving therapies in the future.
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