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Prebiotics Do Not Influence the Severity of Atopic Dermatitis in Infants: A Randomised Controlled Trial

Jan Boženský1, Martin Hill2, Richard Zelenka3

  • 1Paediatrics Department, Vitkovice Hospital, Ostrava, Czech Republic.

Plos One
|November 17, 2015
PubMed

Insights

Hypoallergenic formula with galacto-oligosaccharides did not significantly improve infant atopic dermatitis. The formula was safe and well-tolerated, showing no adverse effects on growth or infections.

Area of Science:

  • Pediatric Nutrition
  • Immunology
  • Dermatology

Background:

  • Atopic dermatitis (AD) is a common inflammatory skin condition in infants.
  • Hypoallergenic (HA) formulas are often used to manage AD.
  • Prebiotics like galacto-oligosaccharides (GOS) are explored for their potential health benefits.

Purpose of the Study:

  • To evaluate the efficacy of a hypoallergenic infant formula supplemented with galacto-oligosaccharides (GOS) in reducing the severity of atopic manifestations.
  • To assess the impact of this supplemented formula on infant growth and infection rates.

Main Methods:

  • A randomized clinical trial was conducted over six months.
  • Infants were assigned to receive either a standard hypoallergenic formula or a hypoallergenic formula supplemented with GOS.
  • Atopic dermatitis severity was measured using the Scoring Atopic Dermatitis (SCORAD) index; anthropometric measurements and infection incidence were also recorded.

Main Results:

  • Both groups exhibited a reduction in average SCORAD scores.
  • No statistically significant difference in SCORAD scores was observed between the GOS-supplemented group and the control group.
  • Anthropometric measurements, tolerance, and incidence of infections showed no significant differences between the groups.

Conclusions:

  • Supplementation of hypoallergenic infant formula with galacto-oligosaccharides did not demonstrate a significant effect on reducing the severity of atopic dermatitis in infants.
  • The supplemented formula was found to be safe and well-tolerated by infants.
  • Further research may be needed to explore the role of prebiotics in infant eczema management.
Abstract

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