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Related Concept Videos

Spindle Assembly02:50

Spindle Assembly

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Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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The Mitotic Spindle02:27

The Mitotic Spindle

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The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
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The Mitotic Spindle02:27

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The Spindle Assembly Checkpoint02:19

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The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
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Destabilization of Microtubules01:45

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The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
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Related Experiment Video

Updated: Mar 30, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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[Spindling in melanomas].

V A Kheinstein, K V Shelekhova

    Voprosy Onkologii
    |November 18, 2015
    PubMed
    Summary

    This study examines spindling in malignant melanomas, covering its biological, morphological, and clinical characteristics. Understanding these features is crucial for accurate diagnosis and treatment of melanoma.

    Area of Science:

    • Oncology
    • Dermatopathology
    • Cancer Biology

    Context:

    • Malignant melanoma is a significant public health concern.
    • Spindling represents a specific morphological feature in melanoma.
    • Understanding spindling is key to melanoma classification.

    Purpose:

    • To provide a comprehensive summary of spindling in malignant melanomas.
    • To integrate biological, morphological, and clinical data on melanoma spindling.
    • To enhance diagnostic accuracy and therapeutic strategies for melanoma.

    Summary:

    • Spindling in malignant melanoma involves elongated neoplastic cells.
    • Biological aspects include genetic alterations and cellular pathways involved.
    • Morphological analysis focuses on cell shape, arrangement, and nuclear features.

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  • Clinical correlations link spindling to tumor behavior and patient outcomes.

    • Impact:

    • Improved understanding of melanoma heterogeneity.
    • Enhanced diagnostic criteria for spindled melanomas.
    • Potential for targeted therapies based on spindling characteristics.
    • Better prediction of melanoma prognosis and patient management.