Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Anatomy and Physiology01:24

Overview of Anatomy and Physiology

40.4K
Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to...
40.4K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

338
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
338
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

450
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
450
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

4.7K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
4.7K
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

372
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
372
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

438
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
438

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of transcranial doppler in localizing stroke lesion: A valuable tool in low resource setting.

The National medical journal of India·2026
Same author

Assessment of Transcranial Doppler (TCD)-based Cerebral Hemodynamics in Preeclamptic Women.

Journal of obstetrics and gynaecology of India·2026
Same author

Association of Heart Rate Variability and NeuroCognitive Performance Among Metabolically Healthy Obese Adults: Cardio-psychological Based Approach.

Annals of neurosciences·2026
Same author

Haptics of Pulse Palpation: Simulation and Validation Through Novel Sensor-Actuator System.

IEEE transactions on haptics·2025
Same author

Comparative evaluation of intraoperative dexmedetomidine versus lidocaine for reducing postoperative cognitive decline in the elderly: a prospective randomized controlled trial.

Anaesthesiology intensive therapy·2024
Same author

Long Sudarshan Kriya Yoga enhances cardiovascular and respiratory synchronization: An observational study.

Journal of Ayurveda and integrative medicine·2024
Same journal

Dr. A.P.J. Abdul Kalam : A Humble Tribute.

Indian journal of physiology and pharmacology·2024
Same journal

Assessment of EEG as a Diagnostic and Prognostic Indicator Tool in the Febrile Seizures.

Indian journal of physiology and pharmacology·2024
Same journal

Ictal EEG Non-linear And High Order Spectral Analysis Methods In Electroconvulsive Therapy And Its Clinical Utility.

Indian journal of physiology and pharmacology·2024
Same journal

Nitric Oxide Synthases Blockade; L-NAME and Estradiol Alter Renal Blood Flow Response to Angiotensin 1-7 in Ovariectomized Rats.

Indian journal of physiology and pharmacology·2024
Same journal

Leptin, Adiponectin and its Molar Ratio as a Biomarker in the Diagnosis of Metabolic Syndrome.

Indian journal of physiology and pharmacology·2024
Same journal

The Effect of Maternal Age, Parity and Heamoglobin Level on Neonatal Birth Weight - A Fru Based Prevalence Study.

Indian journal of physiology and pharmacology·2024
See all related articles

Related Experiment Video

Updated: Mar 30, 2026

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
07:13

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair

Published on: October 7, 2016

14.9K

Translating Physiology for wider applications

K K Deepak

    Indian Journal of Physiology and Pharmacology
    |November 18, 2015
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Measurement of Smooth Muscle Function in the Isolated Tissue Bath-applications to Pharmacology Research
    09:05

    Measurement of Smooth Muscle Function in the Isolated Tissue Bath-applications to Pharmacology Research

    Published on: January 19, 2015

    150.3K
    DNA Transfection of Mammalian Skeletal Muscles using In Vivo Electroporation
    15:56

    DNA Transfection of Mammalian Skeletal Muscles using In Vivo Electroporation

    Published on: October 19, 2009

    18.5K

    Related Experiment Videos

    Last Updated: Mar 30, 2026

    Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
    07:13

    Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair

    Published on: October 7, 2016

    14.9K
    Measurement of Smooth Muscle Function in the Isolated Tissue Bath-applications to Pharmacology Research
    09:05

    Measurement of Smooth Muscle Function in the Isolated Tissue Bath-applications to Pharmacology Research

    Published on: January 19, 2015

    150.3K
    DNA Transfection of Mammalian Skeletal Muscles using In Vivo Electroporation
    15:56

    DNA Transfection of Mammalian Skeletal Muscles using In Vivo Electroporation

    Published on: October 19, 2009

    18.5K