Related Experiment Video
Updated: Aug 10, 2026

Generation of Local CA1 γ Oscillations by Tetanic Stimulation
Published on: August 14, 2015
Low threshold calcium spikes, intrinsic neuronal oscillation and rhythm generation in the CNS
1Department of Physiology, Corob Center for Medical Research, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Abstract:
Field potential studies in vivo have shown that many subcortical structures, such as the inferior olivary nucleus, the thalamic nuclei and the lateral habenular nucleus, generate behaviorally relevant rhythms. In each region, intracellular analysis in brain slices has revealed that activation of a transient, low-threshold calcium current plays a pivotal role in rhythmogenesis. The membrane potential of each individual neuron may oscillate rhythmically as a result of interplay between this current and other inward and outward voltage and calcium-dependent currents. Synchronization of this oscillatory single-cell activity, through mutual interaction and/or appropriately timed afferent drive, results in generation of stereotyped population rhythms.
Related Concept Videos
Electrical Synapses
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Overview of Synapses

