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Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

Omeprazole and Semen Quality.

Saleem A Banihani¹

¹Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.

Basic & Clinical Pharmacology & Toxicology

|November 18, 2015

Summary

Omeprazole (Prilosec) does not appear to affect sperm quality or male fertility. This common acid reducer may even counteract damaging reactive oxygen species, though more research is needed.

Area of Science:

Reproductive Endocrinology
Pharmacology

Background:

Omeprazole is a widely used proton pump inhibitor for acid reduction.
Previous studies have suggested a potential link between omeprazole use and semen quality.

Purpose of the Study:

To systematically review and summarize the existing evidence on the effects of omeprazole on semen quality and male infertility.

Main Methods:

A systematic literature search was conducted using the MEDLINE database.
Keywords included 'omeprazole,' 'sperm,' and 'testosterone.'
References from relevant articles were also reviewed.

Main Results:

Current evidence suggests omeprazole does not significantly alter semen quality.
Omeprazole does not appear to affect basal levels of pituitary-gonadal hormones.

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The drug may possess antioxidant properties, counteracting reactive oxygen species.

Conclusions:

Omeprazole is unlikely to negatively impact male semen quality or fertility.
Further research is warranted to definitively confirm these findings and explore potential protective mechanisms.