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Circulating serum chemerin levels are elevated in lipodystrophy.

Konstanze Miehle¹, Thomas Ebert^1,2, Susan Kralisch¹

¹Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.

Clinical Endocrinology

|November 18, 2015

Summary

Serum chemerin levels are elevated in lipodystrophy (LD) and linked to metabolic complications. Metreleptin treatment did not alter circulating chemerin in LD patients, suggesting chemerin may originate from adipose tissue.

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Area of Science:

Endocrinology
Metabolic Diseases
Adipokine Research

Background:

Lipodystrophy (LD) involves adipose tissue loss and metabolic dysfunction.
Adipokines like chemerin play roles in insulin resistance and inflammation.
Chemerin's role in LD has not been previously investigated.

Purpose of the Study:

To determine serum chemerin levels in lipodystrophy patients.
To assess chemerin mRNA expression in insulin-sensitive tissues of LD mice.
To evaluate the impact of metreleptin treatment on circulating chemerin in LD patients.

Main Methods:

Serum chemerin and metabolic parameters measured in 37 LD patients and 37 controls.
Chemerin mRNA expression analyzed in adipose tissues of LD and control mice.
Circulating chemerin levels monitored in 10 LD patients over one year during metreleptin treatment.

Main Results:

Serum chemerin levels were significantly higher in LD patients compared to controls.
Circulating chemerin positively correlated with HbA1c and CRP levels.
Chemerin mRNA expression increased in visceral and brown adipose tissue of LD mice; metreleptin did not alter circulating chemerin.

Conclusions:

Elevated circulating chemerin is associated with lipodystrophy.
Increased chemerin levels correlate with markers of glucose dysregulation and inflammation.
Visceral and brown adipose tissue may be sources of increased chemerin in LD.