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The hyperlipoproteinemias.

W Patsch1, J R Patsch, A M Gotto

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

The Medical Clinics of North America
|July 1, 1989
PubMed
Summary
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Lowering plasma cholesterol through therapy and lifestyle can prevent atherosclerosis complications. This review covers lipid transport regulation, hyperlipoproteinemias, diagnosis, and risk assessment for heart disease.

Area of Science:

  • Cardiovascular Science
  • Metabolic Disorders
  • Lipidology

Background:

  • The link between abnormal plasma lipid transport and atherosclerosis is well-established.
  • Clinical trials demonstrate cholesterol-lowering therapy's efficacy in preventing atherosclerotic complications.
  • Growing awareness highlights the importance of managing plasma cholesterol levels.

Purpose of the Study:

  • To summarize current knowledge on plasma lipid transport regulation.
  • To discuss primary and secondary hyperlipoproteinemias.
  • To review diagnostic methods and emerging atherosclerosis risk assessment strategies.

Main Methods:

  • Literature review of scientific data on lipid transport and atherogenesis.
  • Analysis of clinical trial outcomes regarding cholesterol-lowering therapies.

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  • Examination of diagnostic approaches for hyperlipidemias and atherosclerosis risk.

    • Main Results:

    • Plasma lipid transport is a complex, regulated process.
    • Hyperlipoproteinemias, both primary and secondary, contribute to atherosclerosis.
    • Dietary measures and pharmacologic interventions effectively lower blood lipids.

    Conclusions:

    • Understanding lipid transport mechanisms is crucial for managing atherosclerosis.
    • Effective therapeutic interventions exist to reduce coronary heart disease risk.
    • Integrated approaches combining diagnosis, lifestyle, and medication are key to cardiovascular health.