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Related Experiment Videos

Transdermal delivery systems.

H P Merkle1

  • 1Institut für Pharmazeutische Technologie, Johann Wolfgang Goethe-Universität, Frankfurt, W. Germany.

Methods and Findings in Experimental and Clinical Pharmacology
|March 1, 1989
PubMed
Summary
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Transdermal delivery systems (TDS) offer promising therapeutic and economic benefits for systemic drug administration. This review covers TDS design, manufacturing, testing, and strategies for enhancing skin permeation.

Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering
  • Dermatology

Background:

  • Transdermal delivery systems (TDS) emerged in the 1970s, gaining significant academic and industrial interest.
  • Marketed products demonstrate the therapeutic potential and economic viability of TDS for systemic therapy.

Purpose of the Study:

  • To provide a comprehensive overview of transdermal drug delivery systems.
  • To detail the fundamentals, design, manufacturing, and testing of TDS.
  • To explore strategies for enhancing transdermal drug permeation.

Main Methods:

  • Review of fundamental principles of transdermal delivery and skin absorption.
  • Discussion on the design, manufacturing, polymers, and adhesives for TDS.
  • Analysis of in vitro and in vivo testing methodologies.

Related Experiment Videos

  • Examination of delivery control principles and modeling.
  • Exploration of strategies to enhance skin permeation and iontophoretic delivery.

    • Main Results:

    • Transdermal drug delivery presents significant therapeutic advantages.
    • Established TDS products highlight the economic potential in the pharmaceutical industry.
    • Various strategies exist to improve drug penetration through the skin.

    Conclusions:

    • Transdermal delivery systems are a well-established and evolving field with substantial therapeutic and economic implications.
    • Understanding skin as an absorption barrier is crucial for effective TDS design.
    • Advanced techniques, including iontophoresis, offer further potential for transdermal drug delivery optimization.