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Related Experiment Videos

Skin permeability.

H Loth1

  • 1Institut für Pharmazeutische Technologie, Universität des Saarlandes, Saarbrücken, W. Germany.

Methods and Findings in Experimental and Clinical Pharmacology
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

This review explores skin permeability and transdermal drug delivery, focusing on how lipid composition and vehicle interactions influence drug penetration. It highlights mechanisms for enhancing drug delivery and discusses implications for altered skin conditions.

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Area of Science:

  • Dermatology
  • Pharmaceutics
  • Physical Chemistry

Background:

  • Skin barrier function is crucial for transdermal drug delivery.
  • Understanding the stratum corneum's lipid structure is key to controlling drug permeation.
  • Vehicle components significantly influence drug penetration and efficacy.

Purpose of the Study:

  • To review the histochemical and physicochemical factors governing skin permeability.
  • To elucidate the mechanisms of drug penetration, vehicle effects, and penetration enhancement.
  • To discuss the implications of altered skin permeability for drug delivery and xenobiotic exposure.

Main Methods:

  • Literature review of skin permeability and transdermal drug permeation.
  • Analysis of horny layer lipid composition and physical order.

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  • Measurement of drug concentration profiles in human skin.
  • Investigation of drug-lipid and vehicle-lipid interactions.

    • Main Results:

    • Drug penetration is fundamentally linked to the chemical and physical properties of the stratum corneum lipids.
    • Vehicles and penetration enhancers modulate drug permeation by interacting with skin lipids.
    • Drug concentration profiles confirm the mechanisms of vehicle effects and penetration enhancement.
    • Pathologically altered skin exhibits increased permeability and xenobiotic accumulation.

    Conclusions:

    • The lipidic structure of the stratum corneum is a primary determinant of transdermal drug transport.
    • Targeted manipulation of lipid interactions offers strategies for effective transdermal drug delivery.
    • Understanding these principles is vital for both normal and diseased skin applications.