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Alterations in Gene Expression in Depression: Prospects for Personalize Patient Treatment
1Biomed Consult Ltd., Swansea, United Kingdom.
Advances in Protein Chemistry and Structural Biology
|November 18, 2015
Summary
Depression is rising globally and often misdiagnosed. This review explores gene expression changes in depression to improve diagnosis and develop personalized treatments.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Global depression rates are increasing, with projections indicating it will be the second leading cause of disability by 2020.
- Misdiagnosis of depression is common due to symptom overlap with anxiety and bipolar disorder, often by non-psychiatrically trained professionals.
Purpose of the Study:
- To review alterations in gene expression associated with depression.
- To enhance understanding of the molecular basis of depression for improved diagnosis and personalized treatment.
Main Methods:
- Literature review focusing on gene expression changes in depression.
- Analysis of molecular mechanisms underlying mood disorders.
Main Results:
- Gene expression alterations are key to understanding depression's molecular underpinnings.
- Identifying specific gene expression patterns can aid in differential diagnosis.
Conclusions:
- A deeper understanding of gene expression in depression is crucial for accurate diagnosis.
- Translational research into mood disorder biochemistry can lead to targeted therapeutics for personalized depression treatment with fewer side effects.
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