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Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation

Omid Assar1, Azim Nejatizadeh, Farzaneh Dehghan

  • 1Alborz University of Medical Sciences, Karaj, Iran. gama.epage@gmail.com.

Global Journal of Health Science
|November 18, 2015
PubMed

Insights

Chlamydia pneumoniae DNA was detected in nearly 30% of atherosclerotic plaques from patients with coronary artery disease. This finding supports a significant association between Chlamydia pneumoniae infection and atherosclerosis development.

Area of Science:

  • Infectious Diseases
  • Cardiovascular Medicine
  • Microbiology

Background:

  • Atherosclerosis is a complex disease with multifactorial origins.
  • The role of infectious agents, particularly Chlamydia pneumoniae, in atherosclerosis pathogenesis remains debated.
  • Conflicting evidence necessitates further investigation into microbial involvement.

Purpose of the Study:

  • To investigate the presence and significance of Chlamydia pneumoniae DNA in atherosclerotic plaques.
  • To determine the association between Chlamydia pneumoniae and coronary artery disease.
  • To compare bacterial presence in diseased arteries versus control tissues.

Main Methods:

  • A cross-sectional study involving 85 patients undergoing coronary artery bypass grafting (CABG).
  • Control group comprised thoracic biopsies from 85 individuals.
  • Nested polymerase chain reaction (PCR) was employed to detect Chlamydia pneumoniae DNA in collected specimens.

Main Results:

  • Chlamydia pneumoniae DNA was identified in 29.4% (25/85) of atherosclerotic plaques.
  • The bacterium was detected in 5.9% (5/85) of internal thoracic artery samples from the control group.
  • A statistically significant association (P=0.0001) was found between C. pneumoniae positivity in atherosclerotic plaques and the control group.

Conclusions:

  • The study findings support the hypothesis linking Chlamydia pneumoniae to atherosclerosis.
  • Chlamydia pneumoniae may be an associated factor in the development of coronary artery disease.
  • Further research is warranted to elucidate the precise role of this bacterium in cardiovascular pathology.

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